Hepatitis B virus infection is one of the most frequent viral infections around the universe showing a major planetary public wellness job. Nowadays, viral hepatitis is the most prima cause of liver malignant neoplastic disease and the most common ground for liver organ transplant. An estimated 4.4million Americans are populating with chronic hepatitis and largely they do non cognize their infection position. About 80,000 new infections occur each and every twelvemonth [ 1 ] . HBV infection is the tenth prima cause of decease worldwide being resulted in 500 000 to 1.2 million deceases per twelvemonth caused by chronic hepatitis, cirrhosis, and hepatocellular carcinoma ; the last histories for 320 000 deceases per twelvemonth [ 2, 3 ] . Round about 15-40 % of septic people have to develop cirrhosis, liver failure, or hepatocellular carcinoma ( HCC ) [ 4 ] . The incidence of HCC has increased worldwide, and now it is the fifth most frequent malignant neoplastic disease histories for killing 300 000-500 000 people each twelvemonth [ 5 ] .
Because of the high morbidity and mortality associated with end-stage liver disease, the economic load of hepatitis B infection is well high. Harmonizing to one US-based survey of New England wellness attention databases, patients with CHB accounted for an norm of $ 40 512 in costs over 2 old ages for wellness attention services and medicine [ 7, 8 ] . Both direct medical costs and indirect costs from work lost as serious liver jobs develop over a figure of old ages.
To cut down planetary HBV-related morbidity and mortality, community base control plan, mass immunisation undertakings and efficacious interventions are indispensable. Although the World Health Organization recommended the executions of mass immunisation plans, since 1991, that decreased the incidence of HBV infection, the prevalence of disease in less developed county among babies, kids, and striplings are still need to take history [ 2 ] . The hepatitis B virus is 50 to 100 times more infective than HIV and an of import occupational jeopardy for wellness workers.
Hepatitis B in Asia
The prevalence of HBV infection is well high in South-East Asia and Sub-Saharan state it is assumed that 90 % of 360 million bearers of the virus globally are constituted in lesser developed states. Of the worldaa‚¬a„?s bearers, 75 % are from the Asiatic continent, where between 8 % and 15 % of the population carry the virus. 8-15 % of the Asiatic continent carries the virus which accounts for 75 % of the worldaa‚¬a„?s bearers [ 9 ] .
The highest HBV infection among the universe is Asia-Pacific part is, and chronic HBV infection in most of the states of that part is high ( & gt ; 10 % prevalence ) [ 10 ] . The infection rates in babies are really high in Thailand, China and Senegal with the prevalence of HBs Ag in serum may transcend 25 % . About 70-90 % of the population of South-east Asia part becomes HBV infected before the age of 40 and bearers are 8 to 20 % [ 11 ] .
Hepatitis B in Thailand
HBV infection is hyper-endemic in Thailand and there are estimated 5 million bearers, 1 in every 20 people. Because of the deficiency of consciousness the infection rate is so high and merely 15 % of those bearer people are being treated for the virus. Cancer is the major cause of decease among the Thai population and in 2006 entirely, 62000 deceases were reported [ 12 ] .
Harmonizing to one survey conducted in 1986 shows the prevalence of HBV markers in general population varies from 40-60 % and estimated 10-20 % of kids between the ages 1-5 old ages have serologic grounds of HBV infection and this prevalence increases with age making a tableland of 40-60 % by age 20. Approximately 75 % of the babes born to HBsAg & A ; HBeAg positive female parents become HBsAg positive at within three months after bringing. The prevalence of chronic bearer varies from 5-10 % and is highest among age groups 10-30 old ages. Primary hepatocellular carcinoma is the first and 3rd most common malignant neoplastic disease among Thai citizens [ 13 ] .
One ethno-epidemiological study for the HBV and HCV infections among seven minorities in a multi-ethnic centre, Northern Thailand ( 2002 ) studied for the prevalence of HBV and HCV infections by the usage of atom agglutination trials shows that overall prevalence of HBs-Ag, anti-HBs and anti-HCV in the seven groups was 10.3, 33.0 and 3.8 % , severally. By look intoing the prevalence of HBV and HCV infection in Thai cultural minorities and demonstrated that HBV was a more common infective agent found in these populations than HCV that showed that HBV and HCV infection are widely spread in rural cultural populations of northern Thailand. A countrywide but community-based epidemiological study is required for the public wellness planning to command their related serious diseases was recommended in this survey [ 14 ] .
A cross-sectional survey was conducted for school-age kids who had no history of HBV inoculation in a low socioeconomic community of Din-Daeng, Bangkok, to look into factors associated with the positiveness of HBV seromarkers. The consequences of this survey expressed the prevalence of HBV seromarkers was 24.85 % , the HBsAg bearer rate was 3.64 % , the anti-HBs positive rate was 15.15 % , and the prevalence of merely anti-HBc was 6.06 % . The consequences revealed the associated factors with HBV positiveness were ( a ) kid factors such as kid ‘s age, sex, ear piercing in female, sharing blade during haircutting, contact lesion from other individuals, utilizing wares with other individuals, seeking things in refuse, and ( B ) household factors such as older parent, parentsaa‚¬a„? low instruction position, low household income, low parent ‘s cognition and attitude about HBV infection and inoculation, ( P & lt ; 0.05 ) [ 15 ] .
Migrant Workers in Thailand
A recent molecular epidemiological survey tried to measure the seroprevalence of HBV and its familial variableness among migratory workers in Thailand from Cambodia, Laos, and Myanmar. The survey was conducted to prove HBs Ag and sera were collected from 1,119 Kampuchean, 787 Laotian, and 1,103 Myanmar workers.The consequence of the survey showed the prevalence of HBsAg among migratory workers from Cambodia, Laos, and Myanmar was 10.8 % , 6.9 % , and 9.7 % , severally. This survey besides revealed that high prevalence of HBV infection ( about 7-11 % ) was found among migratory workers from Cambodia, Laos, and Myanmar, which may reflect the current seroprevalence in their several states [ 16 ] .
Hepatitis B Situation in Myanmar
Myanmar is besides regarded as a state with a high endemicity of HBV infection which is considered as an of import wellness issue by studies carried out among different population groups revealed HBsAg bearer rate of 10-12 % . In Myanmar, although there is possibility of horizontal transmittal through sharing of toothbrushes and razors and iatrogenic transmittal, the perpendicular path of transmittal might be the commonest path by research surveies [ 17 ] . A big graduated table field survey carried out in the whole state showed the magnitude of hepatitis B infection that 10.4 % of the survey population were constituted by seropositive to hepatitis B surface antigen ( HBs Ag ) [ 18 ] . HBsAg bearer rate of 10-12 % was revealed by subsequent survey conducted among different population groups [ 19 ] .
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